In the spring of 2003, Iran sent a message to the US requesting unconditional talks. It wanted to place all issues on the table, ranging from Palestine to Iraq to Lebanon and Iran's nuclear program. Khatami proposed suspending uranium enrichment in exchange for commencing talks with the US.
According to Aria Mehrabi, a member of the leadership council of the New America Foundation, this proposal reached the State Department and was read by Flynt Leverett, the Middle East adviser at the National Security Council. He forwarded it to his superiors, but the proposal died there and Rice, then national security adviser, claimed to have never received it.
In September 2004, the Syrian ambassador to Washington, Imad Moustapha, delivered a letter from the Syrian leadership to the Bush administration, expressing Syria's willingness to cooperate in bring security and stability to Iraq.
The US did not reply. Again, he delivered the same message in 2005, pointing out, however, that if the US wanted Syrian cooperation, political engagement with Damascus must ensue. Again, according to a recent article by the Syrian ambassador, "the US was not interested".